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Article

In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment.

Antimicrobial agents and chemotherapy - 1 Aug 2014

Cannatelli Antonio, Di Pilato Vincenzo, Giani Tommaso, Arena Fabio, Ambretti Simone, Gaibani Paolo, D'Andrea Marco Maria, Rossolini Gian Maria

Abstract excerpt

Colistin is a key drug for the treatment of infections caused by extensively drug-resistant strains of Enterobacteriaceae producing carbapenemases. However, the emergence of colistin resistance is being increasingly reported, especially among Klebsiella pneumoniae strains producing KPC-type carbapenemases (KPC-KP). In this work, we investigated colistin-susceptible (KPB-1) and colistin-resistant (KPB-2)...

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Identifiers

PMID: 24841267
DOI: 10.1128/AAC.02555-14
PMCID: PMC4136067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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