Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An allelic variant of the PmrB sensor kinase responsible for colistin resistance in an Escherichia coli strain of clinical origin.

Scientific reports - 11 Jul 2017

Cannatelli Antonio, Giani Tommaso, Aiezza Noemi, Di Pilato Vincenzo, Principe Luigi, Luzzaro Francesco, Galeotti Cesira L, Rossolini Gian Maria

Abstract excerpt

We investigated the colistin resistance mechanism in an Escherichia coli strain (LC711/14) isolated in Italy in 2014, from an urinary tract infection, which was previously shown to express a colistin resistance mechanism different from mcr-1. LC711/14 was found to carry a novel mutation in the pmrB gene, resulting in a leucine to proline amino acid substitution at position 10 of the PmrB sensor kinase component...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colistin

Share to Drug Resistance, Bacterial

Share to Escherichia coli

Share to Microbial Sensitivity Tests

Share to Protein Structure, Secondary

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 28698568
DOI: 10.1038/s41598-017-05167-6
PMCID: PMC5506025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An allelic variant of the PmrB sensor kinase responsible for colistin resistance in an Escherichia coli strain of clinical origin.PMID 28698568Read ↗

Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin.Semantic proximity Read ↗

In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment.Semantic proximity Read ↗

Mutations in the pmrB gene constitute the major mechanism underlying chromosomally encoded colistin resistance in clinical Escherichia coli.Semantic proximity Read ↗

Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in BacteriaSemantic proximity Read ↗

Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii.Semantic proximity Read ↗

In vivo Emergence of Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Premature Termination of the mgrB Gene RegulatorSemantic proximity Read ↗

MgrB Alterations Mediate Colistin Resistance in Klebsiella pneumoniae Isolates from IranSemantic proximity Read ↗

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae.Semantic proximity Read ↗

MgrB Inactivation Is a Common Mechanism of Colistin Resistance in KPC-Producing Klebsiella pneumoniae of Clinical OriginSemantic proximity Read ↗

Non-clonal emergence of colistin resistance associated with mutations in the BasRS two-component system in <i>Escherichia coli</i> bloodstream isolatesSemantic proximity Read ↗

Genetic Alterations Associated with Colistin Resistance Development in Escherichia coli.Semantic proximity Read ↗

<i>Escherichia coli</i> B-strains are intrinsically resistant to colistin and not suitable for characterization and identification of <i>mcr</i> genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.