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Article

Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin.

Antimicrobial agents and chemotherapy - 1 Aug 2014

Jayol Aurélie, Poirel Laurent, Brink Adrian, Villegas Maria-Virginia, Yilmaz Mesut, Nordmann Patrice

Abstract excerpt

A series of colistin-resistant Klebsiella pneumoniae isolates recovered from different countries was investigated in order to evaluate the involvement of the PmrA/PmrB two-component system in this resistance. Six isolates possessed a mutated PmrB protein, which is encoded by the pmrB gene, part of the pmrCAB operon involved in lipopolysaccharide modification. The same amino acid substitution (Thr157Pro) in PmrB...

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PMID: 24914122
DOI: 10.1128/AAC.00084-14
PMCID: PMC4136042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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