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Article

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae.

The Journal of antimicrobial chemotherapy - 1 Jan 2015

Poirel Laurent, Jayol Aurélie, Bontron Séverine, Villegas Maria-Virginia, Ozdamar Melda, Türkoglu Salih, Nordmann Patrice

Abstract excerpt

OBJECTIVES: Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling system, and acts as a negative regulator on this system. We investigated the role of the MgrB protein as a source of colistin resistance in a series of K. pneumoniae. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25190723
DOI: 10.1093/jac/dku323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae.PMID 25190723Read ↗

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