Article
Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach.
Translational psychiatry - 5 Sept 2017
Lueken U, Kuhn M, Yang Y, Straube B, Kircher T, Wittchen H-U, Pfleiderer B, Arolt V, Wittmann A, Ströhle A, Weber H, Reif A, Domschke K, Deckert J, Lonsdorf T B
Abstract excerpt
Representing a phylogenetically old and very basic mechanism of inhibitory neurotransmission, glycine receptors have been implicated in the modulation of behavioral components underlying defensive responding toward threat. As one of the first findings being confirmed by genome-wide association studies for the phenotype of panic disorder and agoraphobia, allelic variation in a gene coding for the glycine receptor...
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