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Article

Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein.

Molecular and cellular neurosciences - 1 Jun 2007

Calabrese Barbara, Shaked Gideon M, Tabarean Iustin V, Braga Julia, Koo Edward H, Halpain Shelley

Abstract excerpt

In Alzheimer's disease increasing evidence attributes synaptic and cognitive deficits to soluble oligomers of amyloid beta protein (Abeta), even prior to the accumulation of amyloid plaques, neurofibrillary tangles, and neuronal cell death. Here we show that within 1-2 h picomolar concentrations...

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Identifiers

PMID: 17368908
DOI: 10.1016/j.mcn.2007.02.006
PMCID: PMC2268524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17368908-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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