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Article

The m6A pathway facilitates sex determination in Drosophila.

Nature communications - 4 Jul 2017

Kan Lijuan, Grozhik Anya V, Vedanayagam Jeffrey, Patil Deepak P, Pang Nan, Lim Kok-Seong, Huang Yi-Chun, Joseph Brian, Lin Ching-Jung, Despic Vladimir, Guo Jian, Yan Dong, Kondo Shu, Deng Wu-Min, Dedon Peter C, Jaffrey Samie R, Lai Eric C

Abstract excerpt

The conserved modification N6-methyladenosine (m6A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m6A pathway. We first apply miCLIP to map m6A across embryogenesis, characterize its m6A 'writer' complex, validate its YTH 'readers' CG6422 and YT521-B, and generate mutants in five m6A factors. While m6A factors with additional roles in splicing are lethal,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28675155
DOI: 10.1038/ncomms15737
PMCID: PMC5500889

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