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The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation

13 Mar 2020

Abstract excerpt

Deleted in azoospermia-like (DAZL) is an RNA-binding protein critical for gamete development. In full-grown oocytes, the DAZL protein increases 4-fold during reentry into the meiotic cell cycle. Here, we have investigated the functional significance of this accumulation at a genome-wide level. Depletion of DAZL causes a block in maturation and widespread disruption in the pattern of ribosome loading on maternal...

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PMID: 32170089
DOI: 10.1038/s41467-020-15209-9

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