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Article

Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.

Genetics - 1 Feb 2018

Xia Hui, Zhong Chengrong, Wu Xingxing, Chen Ji, Tao Binbin, Xia Xiaoqin, Shi Mijuan, Zhu Zuoyan, Trudeau Vance L, Hu Wei

Abstract excerpt

N6-methyladenosine (m6A), catalyzed by Mettl3 methyltransferase, is a highly conserved epigenetic modification in eukaryotic messenger RNA (mRNA). Previous studies have implicated m6A modification in multiple biological processes, but the in vivo function of m6A has been difficult to study, because mettl3 mutants are embryonic lethal in both mammals and plants. In this study, we have used transcription...

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Identifiers

PMID: 29196300
DOI: 10.1534/genetics.117.300574
PMCID: PMC5788534

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