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Article

SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling

25 Aug 2017

Abstract excerpt

SIRT6 has been identified as an H3K9 deacetylase and a critical regulator of genome stability, telomere integrity, and metabolic homeostasis. Sirt6-deficient mice displayed dramatic phenotypes including profound lymphopenia, loss of subcutaneous fat, lordokyphosis and low bone marrow density. Here, we report that SIRT6 regulates osteogenic differentiation independent of its deacetylase activity in vitro. Further...

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PMID: 28860594
DOI: 10.1038/s41598-017-10323-z

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