Back to search

Article

SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Activating Notch Signaling Via Antagonizing DNMT1

2020-11-02

Abstract excerpt

<h4>Background: </h4> Adipose-derived stem cells (ADSCs) are increasingly accepted as one of ideal seed cells for regenerative medicine for its potential to differentiate into multiple cell types, including osteogenic lineages. Sirtuin proteins 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase and plays important roles in a variety of biological processes, including cell differentiation....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
69c0b684-0f27-55ea-9254-99b8eb5c26dd
DOI
10.21203/rs.3.rs-99004/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SIRT6&nbsp;Promotes&nbsp;Osteogenic Differentiation&nbsp;of&nbsp;Adipose-Derived&nbsp;Mesenchymal Stem Cells&nbsp;Through&nbsp;Activating&nbsp;Notch Signaling&nbsp;Via&nbsp;Antagonizing DNMT1DOI 10.21203/rs.3.rs-99004/v1
SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Activating Notch Signaling via Antagonizing DNMT1Semantic proximity
Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal systemSemantic proximity
SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signalingSemantic proximity
Current understanding and future perspectives of the roles of sirtuins in the reprogramming and differentiation of pluripotent stem cellsSemantic proximity
The Variable Role of SIRT1 in the Maintenance and Differentiation of Mesenchymal Stem CellsSemantic proximity
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2Semantic proximity
SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt SignalingSemantic proximity
SIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiationSemantic proximity
Downregulation of DNA methyltransferase-3a ameliorates the osteogenic differentiation ability of adipose-derived stem cells in diabetic osteoporosisSemantic proximity
SIRT3 Enhances Mesenchymal Stem Cell Longevity and DifferentiationSemantic proximity
Epigenomics Analysis of the Suppression Role of SIRT1 via H3K9 Deacetylation in Preadipocyte DifferentiationSemantic proximity
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.Semantic proximity
Select a neighboring publication to make it the new centre.