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Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties

6 Nov 2023

Abstract excerpt

Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that can differentiate into cells of at least three mesodermal lineages, namely adipocytes, osteoblasts, and chondrocytes, and have potent immunomodulatory properties. Epigenetic modifications are critical regulators of gene expression and cellular differentiation of mesenchymal stem cells (MSCs). Epigenetic machinery controls MSC...

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PMID: 37932257
DOI: 10.1038/s41419-023-06239-4

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