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Article

Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.

Scientific reports - 23 Oct 2013

Piao Jinying, Tsuji Kunikazu, Ochi Hiroki, Iwata Munetaka, Koga Daisuke, Okawa Atsushi, Morita Sadao, Takeda Shu, Asou Yoshinori

Abstract excerpt

Sirtuin 6 (Sirt6) is a mammalian homologue of NAD⁺-dependent histone deacetylase Sir2. Although Sirt6⁻/⁻ mice exhibit growth retardation, the role of Sirt6 in cartilage metabolism is unclear. The aim of this study was to investigate the Sirt6 signaling pathway in cartilage metabolism. Immunohistological evaluation of the tibial growth plate in Sirt6⁻/⁻ mice exhibited impaired proliferation and differentiation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24149372
DOI: 10.1038/srep03022
PMCID: PMC6505680

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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