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Article

The Variable Role of SIRT1 in the Maintenance and Differentiation of Mesenchymal Stem Cells

1 Apr 2018

Abstract excerpt

-dependent deacetylase that acts as a nutrient sensitive regulator of longevity. SIRT1 also acts as a key regulator of mesenchymal stem cells (MSCs), adult stem cells that give rise to tissues such as bone, fat, muscle and cartilage. This review focuses on how SIRT1 regulates the self-renewal, multipotency and differentiation of MSCs. The variable role of SIRT1 in promoting the differentiation of MSCs towards...

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PMID: 29715067
DOI: 10.2217/rme-2017-0128

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