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Article

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth

23 Oct 2014

Abstract excerpt

Sirtuins are NAD+ dependent deacetylases and/or ADP-ribosyl transferases active on histone and non-histone substrates. The first sirtuin was discovered as a transcriptional repressor of the mating-type-loci (Silent Information Regulator sir2) in the budding yeast, where it was shown to extend yeast lifespan. Seven mammalian sirtuins (SIRT1-7) have been now identified with distinct subcellular localization,...

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Identifiers

PMID: 25341037
DOI: 10.1038/cddis.2014.385

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