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Article

Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma

31 Aug 2017

Abstract excerpt

Oesophageal adenocarcinoma (OAC) is one of the ten most prevalent forms of cancer and is showing a rapid increase in incidence and yet exhibits poor survival rates.Compared to many other common cancers, the molecular changes that occur in this disease are relatively poorly understood.However, genes encoding chromatin remodeling enzymes are frequently mutated in OAC.This is consistent with the emerging concept...

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PMID: 28859074
DOI: 10.1371/journal.pgen.1006879

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