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Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility

24 May 2021

Abstract excerpt

Abstract Unlike other malignancies, therapeutic options in pancreatic ductal adenocarcinoma (PDAC) are largely limited to cytotoxic chemotherapy without the benefit of molecular markers predicting response. Here we report tumor-cell-intrinsic chromatin accessibility patterns of treatment-naïve surgically resected PDAC tumors that were subsequently treated with (Gem)/Abraxane adjuvant chemotherapy. By ATAC-seq...

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PMID: 34031415
DOI: 10.1038/s41467-021-23237-2

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