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Article

Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.

Critical care medicine - 1 Mar 2022

Mikacenic Carmen, Bhatraju Pavan, Robinson-Cohen Cassianne, Kosamo Susanna, Fohner Alison E, Dmyterko Victoria, Long S Alice, Cerosaletti Karen, Calfee Carolyn S, Matthay Michael A, Walley Keith R, Russell James A, Christie Jason D, Meyer Nuala J, Christiani David C, Wurfel Mark M

Abstract excerpt

OBJECTIVES: Multiple organ failure in critically ill patients is associated with poor prognosis, but biomarkers contributory to pathogenesis are unknown. Previous studies support a role for Fas cell surface death receptor (Fas)-mediated apoptosis in organ dysfunction. Our objectives were to test for associations between soluble Fas and multiple organ failure, identify protein quantitative trait loci, and...

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Identifiers

PMID: 34593707
DOI: 10.1097/CCM.0000000000005333
PMCID: PMC8863632

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