Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

Intensive care medicine - 1 Mar 2015

Sapru Anil, Calfee Carolyn S, Liu Kathleen D, Kangelaris Kirsten, Hansen Helen, Pawlikowska Ludmila, Ware Lorraine B, Alkhouli Mustafa F, Abbott Jason, Abbot Jason, Matthay Michael A

Abstract excerpt

OBJECTIVE: Thombomodulin (TM) is an activator of protein C and a biomarker for endothelial injury. We hypothesized that (1) elevated plasma levels would be associated with clinical outcomes and (2) polymorphisms in the TM gene would be associated with plasma levels. PATIENTS: We studied 449 patients enrolled in the Fluid and Catheter Treatment Trial (FACTT) for whom both plasma and DNA were available. We used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hospital Mortality

Share to Polymorphism, Single Nucleotide

Share to Respiratory Distress Syndrome

Share to Survival Analysis

Share to Thrombomodulin

Source

Open in PubMed Open full text

Identifiers

PMID: 25643902
DOI: 10.1007/s00134-015-3648-x
PMCID: PMC4500527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.PMID 25643902Read ↗

Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.Semantic proximity Read ↗

Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome.Semantic proximity Read ↗

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and ValidationSemantic proximity Read ↗

Web-based application for predicting the potential target phenotype for recombinant human thrombomodulin therapy in patients with sepsis: analysis of three multicentre registries.Semantic proximity Read ↗

Web-Based Application For Predicting Potential Target Phenotype For Recombinant Human Thrombomodulin Therapy In Patients With Sepsis: Analysis Of Three Multicentre RegistriesSemantic proximity Read ↗

Circulating Mitochondrial DNA as Predictor of Mortality in Critically Ill PatientsSemantic proximity Read ↗

Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome.Semantic proximity Read ↗

Factor V Leiden mutation is associated with improved 30-day survival in patients with acute respiratory distress syndrome.Semantic proximity Read ↗

Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control studySemantic proximity Read ↗

Mitochondrial DNA and Toll-Like Receptor-9 Are Associated With Mortality in Critically Ill PatientsSemantic proximity Read ↗

Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.Semantic proximity Read ↗

Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.