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Article

Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome.

American journal of respiratory cell and molecular biology - 1 Dec 2009

Tejera Paula, Wang Zhaoxi, Zhai Rihong, Su Li, Sheu Chau-Chyun, Taylor Deanne M, Chen Feng, Gong Michelle N, Thompson B Taylor, Christiani David C

Abstract excerpt

Peptidase inhibitor 3 (PI3, elafin) is a protease inhibitor produced locally in the lung, where it plays a central role in controlling excessive activity of neutrophil elastase. Our previous study revealed that PI3 gene expression is down-regulated during the acute stage of acute respiratory dist...

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Identifiers

PMID: 19251943
DOI: 10.1165/rcmb.2008-0410OC
PMCID: PMC2784407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19251943-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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