Article
Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
Critical care (London, England) - 23 May 2016
Sapru Anil, Liu Kathleen D, Wiemels Joseph, Hansen Helen, Pawlikowska Ludmilla, Poon Annie, Jorgenson Eric, Witte John S, Calfee Carolyn S, Ware Lorraine B, Matthay Michael A
Abstract excerpt
BACKGROUND: Altered plasma levels of protein C, thrombomodulin, and the endothelial protein C receptor are associated with poor clinical outcomes in patients with acute respiratory distress syndrome (ARDS). We hypothesized that common variants in these genes would be associated with mortality as well as ventilator-free and organ failure-free days in patients with ARDS. METHODS: We genotyped linkage...
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