Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two alternative pathways for generating transmissible prion disease de novo.

Acta neuropathologica communications - 10 Nov 2015

Makarava Natallia, Savtchenko Regina, Baskakov Ilia V

Abstract excerpt

INTRODUCTION: Previous studies established that prion disease with unique strain-specific phenotypes could be induced by in vitro-formed recombinant PrP (rPrP) fibrils with structures different from that of authentic prions, or PrP(Sc). To explain the etiology of prion diseases, new mechanism proposed that in animals the transition from rPrP fibrils to PrP(Sc) consists of two main steps: the first involves...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid
Share to Brain
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Prion Diseases

Share to Prions

Share to Protein Folding

Share to Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26556038
DOI: 10.1186/s40478-015-0248-5
PMCID: PMC4641408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two alternative pathways for generating transmissible prion disease de novo.PMID 26556038Read ↗

[Molecular bases of prion diseases].Semantic proximity Read ↗

Selective amplification of classical and atypical prions using modified protein misfolding cyclic amplification.Semantic proximity Read ↗

De novo generation of infectious prions in vitro produces a new disease phenotype.Semantic proximity Read ↗

Pathogenicity, strain properties and interspecies transmission capacity of pure recombinant prion protein assembliesSemantic proximity Read ↗

Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?Semantic proximity Read ↗

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome.Semantic proximity Read ↗

Prion diseases: a riddle wrapped in a mystery inside an enigma.Semantic proximity Read ↗

Prion strains: shining new light on old concepts.Semantic proximity Read ↗

A closer look at prion strains: characterization and important implications.Semantic proximity Read ↗

Molecular foundations of prion strain diversity.Semantic proximity Read ↗

Prions: What Are They Good For?Semantic proximity Read ↗

How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.