Article

Pathogenicity, strain properties and interspecies transmission capacity of pure recombinant prion protein assemblies

2023-02-27

Abstract excerpt

The pathogenicity of fibrillar assemblies derived from bacterially expressed recombinant prion protein (rPrP) has been key to the demonstration that prions are infectious proteins responsible for human and animal transmissible spongiform encephalopathies. Yet, their use in identifying which structural PrP features are important for prion biology, including strain properties and capacity to transmit between species...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 21f8af61-fa6c-517f-b734-077de7f2cfe0
DOI: 10.1101/2023.02.27.530231

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathogenicity, strain properties and interspecies transmission capacity of pure recombinant prion protein assembliesDOI 10.1101/2023.02.27.530231Read

Prion strains: shining new light on old concepts.Semantic proximity Read

Prion replication environment defines the fate of prion strain adaptation.Semantic proximity Read

Prion Strain Diversity.Semantic proximity Read

A closer look at prion strains: characterization and important implications.Semantic proximity Read

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases.Semantic proximity Read

Changes in prion replication environment cause prion strain mutation.Semantic proximity Read

Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype.Semantic proximity Read

Prions.Semantic proximity Read

High-resolution structure and strain comparison of infectious mammalian prions.Semantic proximity Read

Divergent prion strain evolution driven by PrPC expression level in transgenic mice.Semantic proximity Read

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in NeurodegenerationSemantic proximity Read

Prion strain mutation determined by prion protein conformational compatibility and primary structure.Semantic proximity Read