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Article

Role of viral and host factors in determining the outcome of HBV-associated acute liver failure.

Journal of translational medicine - 25 Jun 2026

Farci Patrizia, Battista Davide De, Engle Ronald E, Chu Eric, Chen Zhaochun, Jeffrey Brendan, Rule Jody, Nguyen Hanh, Raini Sandra, Takeda Soichi, Follman Dean, Alter Harvey J, Lee William M

Abstract excerpt

BACKGROUND: Acute hepatitis B virus (HBV) infection encompasses a broad clinical spectrum, from self-limited hepatitis to acute liver injury (ALI), acute liver failure (ALF), subacute liver failure, and ALF on chronic HBV reactivation. This study investigates how host and viral factors interact to shape the clinical spectrum of HBV-associated ALF. METHODS: We analyzed 231 serial serum samples from 49...

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Share to Cytokines
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hepatitis B

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Share to Host-Pathogen Interactions

Share to Liver Failure, Acute

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Source

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Identifiers

PMID: 42351169
DOI: 10.1186/s12967-026-08347-z
PMCID: PMC13326087

Genes

MIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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