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Liver humanized NSG-PiZ mice support the study of chronic hepatitis B virus infection and antiviral therapies

2022-05-17

Abstract excerpt

Hepatitis B virus (HBV) is a pathogen of major public health importance that is largely incurable once a chronic hepatitis B (CHB) infection is established. Only humans and great apes are fully permissive to HBV replication, and this species restriction has impacted HBV research by limiting the utility of small animal models of HBV. To combat the species restriction of HBV and enable more HBV studies in vivo , li...

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Identifiers and source

Literature Corpus work
a2b68a6e-5a70-5deb-9440-2b41835365b5
DOI
10.1101/2022.05.17.492375
Open publication

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Liver humanized NSG-PiZ mice support the study of chronic hepatitis B virus infection and antiviral therapiesDOI 10.1101/2022.05.17.492375
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