Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary analysis of classical HLA class I and II genes suggests that recent positive selection acted on DPB1*04:01 in Japanese population.

PloS one - 1 Jan 2012

Kawashima Minae, Ohashi Jun, Nishida Nao, Tokunaga Katsushi

Abstract excerpt

The human leukocyte antigen (HLA) genes exhibit the highest degree of polymorphism in the human genome. This high degree of variation at classical HLA class I and class II loci has been maintained by balancing selection for a long evolutionary time. However, little is known about recent positive selection acting on specific HLA alleles in a local population. To detect the signature of recent positive selection,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histocompatibility Antigens Class I
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-A Antigens

Share to HLA-B Antigens

Share to HLA-C Antigens

Share to HLA-DP beta-Chains

Share to HLA-DQ beta-Chains

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23056460
DOI: 10.1371/journal.pone.0046806
PMCID: PMC3463557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary analysis of classical HLA class I and II genes suggests that recent positive selection acted on DPB1*04:01 in Japanese population.PMID 23056460Read ↗

Strong and unique associations of HLA-DPB1 alleles with other HLA antigens in a Japanese population.Semantic proximity Read ↗

Sequence-based association analysis of HLA class I and II alleles in Japanese supports conservation of common haplotypes.Semantic proximity Read ↗

Establishment of NGS-based HLA 9-locus haplotypes in the Eastern Han Chinese population highlights the role of HLA-DP in donor selection for transplantation.Semantic proximity Read ↗

Determination of HLA-A, -C, -B, -DRB1 allele and haplotype frequency in Japanese population based on family study.Semantic proximity Read ↗

Catalog of 162 single nucleotide polymorphisms (SNPs) in a 4.7-kb region of the HLA-DP loci in southern Chinese ethnic groups.Semantic proximity Read ↗

Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles.Semantic proximity Read ↗

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.Semantic proximity Read ↗

HLA and SNP haplotype mapping in the Japanese population.Semantic proximity Read ↗

Variation of HLA-DPB1 Gene in Hepatitis B InfectionSemantic proximity Read ↗

HLA class I haplotype diversity is consistent with selection for frequent existing haplotypes.Semantic proximity Read ↗

Impact of highly conserved HLA haplotype on acute graft-versus-host disease.Semantic proximity Read ↗

[Analysis of Gene Recombination between HLA-B and -DRB1, HLA-DQB1 and -DPB1 Loci].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.