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Article

Proteome response at the edge of protein aggregation.

Open biology - 1 Feb 2015

Sanchez de Groot Natalia, Gomes Ricardo A, Villar-Pique Anna, Babu M Madan, Coelho Ana Varela, Ventura Salvador

Abstract excerpt

Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison of two amyloid-β-peptide variants, mostly insoluble but differently recruited by the cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25673330
DOI: 10.1098/rsob.140221
PMCID: PMC4345283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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