Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.

Cell systems - 27 Sept 2017

Ryl Tatsiana, Kuchen Erika E, Bell Emma, Shao Chunxuan, Flórez Andrés F, Mönke Gregor, Gogolin Sina, Friedrich Mona, Lamprecht Florian, Westermann Frank, Höfer Thomas

Abstract excerpt

While many tumors initially respond to chemotherapy, regrowth of surviving cells compromises treatment efficacy in the long term. The cell-biological basis of this regrowth is not understood. Here, we characterize the response of individual, patient-derived neuroblastoma cells driven by the prominent oncogene MYC to the first-line chemotherapy, doxorubicin. Combining live-cell imaging, cell-cycle-resolved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Doxorubicin

Share to Models, Theoretical

Share to Neuroblastoma

Share to Primary Cell Culture

Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 28843484
DOI: 10.1016/j.cels.2017.07.005

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.PMID 28843484Read ↗

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastomaSemantic proximity Read ↗

Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister CellsSemantic proximity Read ↗

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell lineSemantic proximity Read ↗

Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN -Amplified CancersSemantic proximity Read ↗

Methods and sensors for functional genomic studies of cell-cycle transitions in single cells.Semantic proximity Read ↗

Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanomaSemantic proximity Read ↗

Decoding cancer dormancy: integrative genomic, phenotypic and live-cell imaging analysis to reveal the hidden cancer cell reservoir.Semantic proximity Read ↗

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.Semantic proximity Read ↗

MYC Is a Major Determinant of Mitotic Cell FateSemantic proximity Read ↗

Cycling cancer persister cells arise from lineages with distinct transcriptional and metabolic programsSemantic proximity Read ↗

Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.Semantic proximity Read ↗

GPX4-VIM equates a proliferating DTP state in TNBC subtypes with converged vulnerabilities to autophagy and glutathione inhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.