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Article

MYC Is a Major Determinant of Mitotic Cell Fate

1 Jul 2015

Abstract excerpt

Taxol and other antimitotic agents are frontline chemotherapy agents but the mechanisms responsible for patient benefit remain unclear. Following a genome-wide siRNA screen, we identified the oncogenic transcription factor Myc as a taxol sensitizer. Using time-lapse imaging to correlate mitotic behavior with cell fate, we show that Myc sensitizes cells to mitotic blockers and agents that accelerate mitotic...

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Identifiers

PMID: 26175417
DOI: 10.1016/j.ccell.2015.06.001

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