Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril.

Biochemical pharmacology - 1 Apr 2009

Zhu Hao-Jie, Appel David I, Johnson Julie A, Chavin Kenneth D, Markowitz John S

Abstract excerpt

Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are the major hydrolytic enzymes responsible for the metabolism of numerous therapeutic agents as well as endogenous substrates. CES1 and CES2 differ distinctly in their substrate specificity and tissue distribution. In this study, we investigated the role of CES1 and CES2 in converting the antihypertensive prodrug trandolapril to its more active form...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antihypertensive Agents
Share to Carboxylic Ester Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Genetic Variation

Share to Hydrolysis

Share to Indoles

Share to Organ Specificity

Share to Substrate Specificity

Source

Identifiers

PMID: 19185566
DOI: 10.1016/j.bcp.2008.12.017

Genes

CES1
CES2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril.PMID 19185566Read ↗

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers.Semantic proximity Read ↗

CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors.Semantic proximity Read ↗

A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms.Semantic proximity Read ↗

CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril.Semantic proximity Read ↗

Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators.Semantic proximity Read ↗

The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.Semantic proximity Read ↗

Pharmacogenetic study of CES1 gene and enalapril efficacy.Semantic proximity Read ↗

Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability.Semantic proximity Read ↗

The Impact of Carboxylesterases in Drug Metabolism and PharmacokineticsSemantic proximity Read ↗

Carboxylesterase 1 genetic variability, expression and potential for drug-drug interactionsSemantic proximity Read ↗

Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.Semantic proximity Read ↗

Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.