Article
Phospholipase D2 loss results in increased blood pressure via inhibition of the endothelial nitric oxide synthase pathway.
Scientific reports - 22 Aug 2017
Nelson Rochelle K, Ya-Ping Jiang, Gadbery John, Abedeen Danya, Sampson Nicole, Lin Richard Z, Frohman Michael A
Abstract excerpt
The Phospholipase D (PLD) superfamily is linked to neurological disease, cancer, and fertility, and a recent report correlated a potential loss-of-function PLD2 polymorphism with hypotension. Surprisingly, PLD2 -/- mice exhibit elevated blood pressure accompanied by associated changes in cardiac performance and molecular markers, but do not have findings consistent with the metabolic syndrome. Instead, expression...
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