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Article

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2015

Kirkby Nicholas S, Reed Daniel M, Edin Matthew L, Rauzi Francesca, Mataragka Stefania, Vojnovic Ivana, Bishop-Bailey David, Milne Ginger L, Longhurst Hilary, Zeldin Darryl C, Mitchell Jane A, Warner Timothy D

Abstract excerpt

Eicosanoids are important vascular regulators, but the phospholipase A2 (PLA2) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss-of-function mutation in group IVA cytosolic phospholipase A2 (cPLA2α). Chromatography/mass spectrometry was used to...

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Identifiers

PMID: 26183771
DOI: 10.1096/fj.15-275065
PMCID: PMC4608906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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