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Article

The Proprioceptive System Masterminds Spinal Alignment: Insight into the Mechanism of Scoliosis.

Developmental cell - 21 Aug 2017

Blecher Ronen, Krief Sharon, Galili Tal, Biton Inbal E, Stern Tomer, Assaraf Eran, Levanon Ditsa, Appel Elena, Anekstein Yoram, Agar Gabriel, Groner Yoram, Zelzer Elazar

Abstract excerpt

Maintaining posture requires tight regulation of the position and orientation of numerous spinal components. Yet, surprisingly little is known about this regulatory mechanism, whose failure may result in spinal deformity as in adolescent idiopathic scoliosis. Here, we use genetic mouse models to demonstrate the involvement of proprioception in regulating spine alignment. Null mutants for Runx3 transcription...

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Share to Core Binding Factor Alpha 3 Subunit
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28829946
DOI: 10.1016/j.devcel.2017.07.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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