Article
Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.
Neuron - 17 Aug 2016
Hilde Kathryn L, Levine Ariel J, Hinckley Christopher A, Hayashi Marito, Montgomery Jessica M, Gullo Miriam, Driscoll Shawn P, Grosschedl Rudolf, Kohwi Yoshinori, Kohwi-Shigematsu Terumi, Pfaff Samuel L
Abstract excerpt
Motor behaviors such as walking or withdrawing the limb from a painful stimulus rely upon integrative multimodal sensory circuitry to generate appropriate muscle activation patterns. Both the cellular components and the molecular mechanisms that instruct the assembly of the spinal sensorimotor system are poorly understood. Here we characterize the connectivity pattern of a sub-population of lamina V inhibitory...
Topics
- Animals
- Extremities
- Interneurons
- Matrix Attachment Region Binding Proteins
- Mice
- Mice, Knockout
- Mutation
- Neural Pathways
- Pain
- Reflex
- Sensory Receptor Cells
- Spinal Cord
- Transcription Factors