Article
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements.
Nature - 17 Mar 1994
Klein R, Silos-Santiago I, Smeyne R J, Lira S A, Brambilla R, Bryant S, Zhang L, Snider W D, Barbacid M
Abstract excerpt
The trkC gene is expressed throughout the mammalian nervous system and encodes a series of tyrosine protein kinase isoforms that serve as receptors for neurotrophin-3 (NT3), a member of the nerve growth factor (NGF) family of neurotrophic factors. One of these isoforms, gp145trkC/TrkC K1, mediates the trophic properties of NT3 in cultured cells. Here we show that homozygous mice defective for TrkC tyrosine...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Count
- Clone Cells
- DNA
- Ganglia, Spinal
- Heterozygote
- Homozygote
- Mice
- Mice, Inbred C57BL