Article
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.
Nature - 30 Aug 2012
Andersson Lisa S, Larhammar Martin, Memic Fatima, Wootz Hanna, Schwochow Doreen, Rubin Carl-Johan, Patra Kalicharan, Arnason Thorvaldur, Wellbring Lisbeth, Hjälm Göran, Imsland Freyja, Petersen Jessica L, McCue Molly E, Mickelson James R, Cothran Gus, Ahituv Nadav, Roepstorff Lars, Mikko Sofia, Vallstedt Anna, Lindgren Gabriella, Andersson Leif, Kullander Klas
Abstract excerpt
Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement. These networks produce left-right alternation of limbs as well as coordinated activation of flexor and extensor muscles. Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses. The mutation is...
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