Article

Active and Passive Mechanical Deficits Precede Spinal Curvature in a Zebrafish Model of Idiopathic Scoliosis

2026-05-03

Abstract excerpt

Idiopathic scoliosis is a common spinal disorder characterized by progressive three-dimensional curvature of unknown cause. Although biomechanical imbalance has long been proposed to contribute to scoliosis, the early physiological states that precede curvature onset remain poorly understood. Here, we investigated this problem using zebrafish uts2r3 mutants, which develop fully penetrant juvenile-onset spinal cur...

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Literature Corpus work: c6125ef0-a39c-5ce6-9e81-7ae09a783588
DOI: 10.64898/2026.04.29.721663

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