Article
Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity.
Nature communications - 23 Jun 2020
Assaraf Eran, Blecher Ronen, Heinemann-Yerushalmi Lia, Krief Sharon, Carmel Vinestock Ron, Biton Inbal E, Brumfeld Vlad, Rotkopf Ron, Avisar Erez, Agar Gabriel, Zelzer Elazar
Abstract excerpt
In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abnormalities. While loss of Piezo2 in chondrogenic or osteogenic lineages does not lead to human-like skeletal...
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