Article
The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis.
Developmental biology - 15 Apr 2001
Tourtellotte W G, Keller-Peck C, Milbrandt J, Kucera J
Abstract excerpt
The Egr family of zinc-finger transcription factors, consisting of Egr1, Egr2, Egr3, and Egr4, are involved in cellular growth and differentiation. Adult Egr3-deficient mice are ataxic and lack muscle spindle proprioceptors that normally develop at the sites of Ia afferent-myotube contacts during embryogenesis. To resolve whether spindles form and then degenerate, or whether they never form in the absence of...
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