Article
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons.
The EMBO journal - 1 Jul 2002
Levanon Ditsa, Bettoun David, Harris-Cerruti Catherine, Woolf Eilon, Negreanu Varda, Eilam Raya, Bernstein Yael, Goldenberg Dalia, Xiao Cuiying, Fliegauf Manfred, Kremer Eitan, Otto Florian, Brenner Ori, Lev-Tov Aharon, Groner Yoram
Abstract excerpt
The RUNX transcription factors are important regulators of linage-specific gene expression in major developmental pathways. Recently, we demonstrated that Runx3 is highly expressed in developing cranial and dorsal root ganglia (DRGs). Here we report that within the DRGs, Runx3 is specifically expressed in a subset of neurons, the tyrosine kinase receptor C (TrkC) proprioceptive neurons. We show that...
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