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Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells

5 Oct 2020

Abstract excerpt

Abstract Cell division cycle 6 ( Cdc6 ) plays key roles in regulating DNA replication, and activation and maintenance of cell cycle check points. In addition, Cdc6 exerts oncogenic properties via genomic instability associated with incomplete DNA replication. This study aimed to examine the effects of Cdc6 on pancreatic cancer (PC) cells. Our results showed that Cdc6 expression was higher in clinical PC specimens...

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PMID: 33020506
DOI: 10.1038/s41598-020-73474-6

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