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The critical role of mode of action studies in kinetoplastid drug discovery

10 May 2023

Abstract excerpt

Understanding the target and mode of action of compounds identified by phenotypic screening can greatly facilitate the process of drug discovery and development. Here, we outline the tools currently available for target identification against the neglected tropical diseases, human African trypanosomiasis, visceral leishmaniasis and Chagas' disease. We provide examples how these tools can be used to identify and...

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PMID: 37600222
DOI: 10.3389/fddsv.2023.1185679

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