Article

Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in <i>Toxoplasma gondii</i>

2018-08-03

Abstract excerpt

Toxoplasma gondii and related human parasites contain an essential plastid organelle called the apicoplast. Clinically-used antibiotics and other inhibitors that disrupt apicoplast biogenesis cause a mysterious “delayed-death” phenotype, in which parasite growth is unaffected during the first lytic cycle of inhibitor treatment but is severely inhibited in the second lytic cycle even after drug removal. Critical to...

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Literature Corpus work: 129f83cd-e144-5ced-a67b-19d28d7fd4dd
DOI: 10.1101/384123

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