Article
Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice.
Endocrinology - 1 Dec 2016
Darcy Justin, McFadden Samuel, Fang Yimin, Huber Joshua A, Zhang Chi, Sun Liou Y, Bartke Andrzej
Abstract excerpt
Ames dwarf mice (Prop1df/df) are long-lived due to a loss of function mutation, resulting in deficiency of GH, TSH, and prolactin. Along with a marked extension of longevity, Ames dwarf mice have improved energy metabolism as measured by an increase in their oxygen consumption and heat production, as well as a decrease in their respiratory quotient. Along with alterations in energy metabolism, Ames dwarf mice...
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