Sexual dimorphism of MASLD-driven bone loss

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is highly prevalent with major risk of progression to Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Hepatocellular Carcinoma (HCC). Recently, osteoporosis and bone fracture have emerged as sexually-dimorphic comorbidities of MASLD yet the mechanisms of this bone loss are unknown. Herein, we address these knowledge gap...

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• Mice, Knockout
• Mice, Inbred BALB C
• Absorptiometry, Photon
• ATP Binding Cassette Transporter, Subfamily B
• Bone and Bones
• Bone Density
• Real-Time Polymerase Chain Reaction
• Reverse Transcriptase Polymerase Chain Reaction

Identifiers and source

Literature Corpus work

74f71a66-e915-546d-b7b3-1437590a99a6

DOI

10.1101/2024.11.25.625246