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Article

B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis

18 Aug 2017

Abstract excerpt

<h3>Objectives</h3> <i>TNFSF4</i> (encodes OX40L) is a susceptibility locus for systemic lupus erythematosus (SLE). Risk alleles increase <i>TNFSF4</i> expression in cell lines, but the mechanism linking this effect to disease is unclear, and the OX40L-expressing cell types mediating the risk are not clearly established. Blockade of OX40L has been demonstrated to reduce disease severity in several models of...

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PMID: 28818832
DOI: 10.1136/annrheumdis-2017-211499

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