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Article

Blockade of OX40/OX40L signaling using anti‐OX40L alleviates murine lupus nephritis

27 May 2024

Abstract excerpt

Abstract Genetic variants of the OX40 ligand (OX40L) locus are associated with the risk of systemic lupus erythematosus (SLE), it is unclear how the OX40L blockade delays the lupus phenotype. Therefore, we examined the effects of an anti‐OX40L antibody in MRL/Lpr mice. Next, we investigated the effect of anti‐OX40L on immunosuppression in keyhole limpet hemocyanin‐immunized C57BL/6J mice. In vitro treatment of...

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Identifiers

PMID: 38798163
DOI: 10.1002/eji.202350915

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