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Article

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.

Nature genetics - 1 Jan 2008

Cunninghame Graham Deborah S, Graham Robert R, Manku Harinder, Wong Andrew K, Whittaker John C, Gaffney Patrick M, Moser Kathy L, Rioux John D, Altshuler David, Behrens Timothy W, Vyse Timothy J

Abstract excerpt

Systemic lupus erythematosus (SLE) is a multisystem complex autoimmune disease of uncertain etiology (OMIM 152700). Over recent years a genetic component to SLE susceptibility has been established. Recent successes with association studies in SLE have identified genes including IRF5 (refs. 4,5) a...

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Share to Cells, Cultured
Share to Haplotypes
Share to Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to OX40 Ligand

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 18059267
DOI: 10.1038/ng.2007.47
PMCID: PMC3705866

Genes

TNFSF4
TNFRSF4
TNF
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18059267-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.PMID 18059267Read ↗

The molecular genetic basis of the association of TNFSF4 with SLESemantic proximity Read ↗

Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis.Semantic proximity Read ↗

Association of TNFSF4 Gene Polymorphisms and Plasma TNFSF4 Level with Risk of Systemic Lupus Erythematosus in a Chinese Population.Semantic proximity Read ↗

Association of TNFSF4 polymorphisms with systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

Haplotype structure of TNFRSF5-TNFSF5 (CD40-CD40L) and association analysis in systemic lupus erythematosus.Semantic proximity Read ↗

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.Semantic proximity Read ↗

Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus.Semantic proximity Read ↗

Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population.Semantic proximity Read ↗

A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort.Semantic proximity Read ↗

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.Semantic proximity Read ↗

Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis.Semantic proximity Read ↗

TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population.Semantic proximity Read ↗

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