Article

Blockade of OX40/OX40L signaling using anti-OX40L delays disease progression in murine lupus

2023-07-11

Abstract excerpt

<h4>Objectives: </h4> OX40 ligand (OX40L) locus genetic variants have relationships with the risk for systemic lupus erythematosus (SLE), OX40L blockade has been shown to ameliorate renal damage and suppress autoantibody production in NZB/W F1 mice. However, it is unclear how OX40L blockade delays lupus phenotype. Methods In present study, we examined the impact of blocking OX40L using anti-OX40L in the MRL/lpr m...

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Literature Corpus work: 4b7e4fa2-8a21-5210-9631-72311220f88d
DOI: 10.21203/rs.3.rs-3139603/v1

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