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Article

Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.

Biophysical journal - 19 Sept 2017

Zdanowicz Rafal, Kreutzberger Alex, Liang Binyong, Kiessling Volker, Tamm Lukas K, Cafiso David S

Abstract excerpt

Complexin-1 is a SNARE effector protein that decreases spontaneous neurotransmitter release and enhances evoked release. Complexin binds to the fully assembled four-helical neuronal SNARE core complex as revealed in competing molecular models derived from x-ray crystallography. Presently, it is unclear how complexin binding to the postfusion complex accounts for its effects upon spontaneous and evoked release...

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Identifiers

PMID: 28456331
DOI: 10.1016/j.bpj.2017.04.002
PMCID: PMC5607037

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